1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase

1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16, N-(5-phospho-D-ribosylformimino)-5-amino-1-(5-phosphoribosyl)-4-imidazolecarboxamide isomerase, phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase, N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase, 1-(5-phosphoribosyl)-5-imidazole-4-carboxamide ketol-isomerase) is an enzyme with systematic name 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide aldose-ketose-isomerase. This enzyme catalyses the following chemical reaction

1-(5-phosphoribosyl)-5-imidazole-4-carboxamide

\rightleftharpoons

5--1-(5-phosphoribosyl)imidazole-4-carboxamide

References

Margolies MN, Goldberger RF (July 1966). "Isolation of the fourth (isomerase) of histidine biosynthesis from Salmonella typhimurium". The Journal of Biological Chemistry. 241 (14): 3262–9. PMID 5330429.

External links

1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide+isomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Isomerases: intramolecular oxidoreductases (EC 5.3)
5.3.1: Aldoses/Ketoses	Triosephosphate isomerase Ribose-5-phosphate isomerase Mannose phosphate isomerase Glucose isomerase
5.3.2: Keto/Enol	Phenylpyruvate tautomerase Oxaloacetate tautomerase 4-Oxalocrotonate tautomerase
5.3.3: C = C	Steroid D-isomerase Isopentenyl-diphosphate delta isomerase Vinylacetyl-CoA D-isomerase Muconolactone D-isomerase Cholestenol Delta-isomerase (EBP) Methylitaconate D-isomerase Aconitate Delta-isomerase Enoyl CoA isomerase Prostaglandin-A1 Delta-isomerase 5-carboxymethyl-2-hydroxymuconate D-isomerase Isopiperitenone D-isomerase L-dopachrome isomerase Polyenoic fatty acid isomerase
5.3.4: S-S	Protein disulfide-isomerase (PDIA3)
5.3.99: other	Prostaglandin D2 synthase/Prostaglandin-D synthase Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 5.3.1