| 2-coumarate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.11 | ||||||||
| CAS no. | 37251-10-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction
- 3-(2-hydroxyphenyl)propanoate + NAD 2-coumarate + NADH + H
2-coumarate + NADH + HThus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD, whereas its 3 products are 2-coumarate, NADH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.
References
- Levy CC, Weinstein GD (December 1964). "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry. 3 (12): 1944–7. doi:10.1021/bi00900a027. PMID 14269315.
| Oxidoreductases: CH–CH oxidoreductases (EC 1.3) | |
|---|---|
| 1.3.1: NAD/NADP acceptor | |
| 1.3.3: Oxygen acceptor | |
| 1.3.5: Quinone | |
| 1.3.99: Other acceptors | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
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