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The 2018–19 CAF Confederation Cup knockout stage will be played from 7 April to 26 May 2019. A total of eight teams will compete in the knockout stage to decide the champions of the 2018–19 CAF Confederation Cup.
Qualified teams
The winners and runners-up of each of the four groups in the group stage advance to the quarter-finals.
In the knockout stage, the eight teams play a single-elimination tournament. Each tie is played on a home-and-away two-legged basis. If the aggregate score is tied after the second leg, the away goals rule will be applied, and if still tied, extra time will not be played, and the penalty shoot-out will be used to determine the winner (Regulations III. 26 & 27).
Schedule
The schedule of each round is as follows. Effective from the Confederation Cup group stage, weekend matches are played on Sundays while midweek matches are played on Wednesdays, with some exceptions. Kick-off times are also fixed at 13:00, 16:00 and 19:00 GMT.
Round
First leg
Second leg
Quarter-finals
7 April 2019
14 April 2019
Semi-finals
28 April 2019
5 May 2019
Final
19 May 2019
26 May 2019
Bracket
The bracket of the knockout stage is determined as follows:
Round
Matchups
Quarter-finals
(Group winners host second leg, matchups decided by draw, teams from same group cannot play each other)
QF1
QF2
QF3
QF4
Semi-finals
(Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
SF1
SF2
Final
(Winners SF1 host first leg, Winners SF2 host second leg)
Winner SF1 vs. Winner SF2
The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 20 March 2019, 19:00 CAT (UTC+2), at the Marriot Hotel in Cairo, Egypt.
In the quarter-finals, the winners of one group played the runners-up of another group (teams from same group could not play each other), with the group winners hosting the second leg, and the matchups decided by draw.