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In enzymology, a 6-oxohexanoate dehydrogenase (EC 1.2.1.63) is an enzyme that catalyzes the chemical reaction

6-oxohexanoate + NADP + H₂O ${\displaystyle \rightleftharpoons }$ adipate + NADPH + 2 H

The 3 substrates of this enzyme are 6-oxohexanoate, NADP, and H₂O, whereas its 3 products are adipate, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP+ oxidoreductase. This enzyme participates in caprolactam degradation.

References

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• Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1): 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571.
• Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.

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