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ACYP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K7J, 2K7K, 2VH7, 2W4C, 2W4P, 3TOQ
Identifiers
Aliases	ACYP1, ACYPE, acylphosphatase 1
External IDs	OMIM: 600875; MGI: 1913454; HomoloGene: 11932; GeneCards: ACYP1; OMA:ACYP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3 Start 75,053,237 bp End 75,069,483 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 D1 Start 85,319,172 bp End 85,335,212 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lung ventricular zone ganglionic eminence Pituitary Gland middle temporal gyrus anterior pituitary Brodmann area 9 right lobe of thyroid gland C1 segment Top expressed in seminiferous tubule spermatocyte spermatid facial motor nucleus choroid plexus of fourth ventricle intercostal muscle lobe of cerebellum deep cerebellar nuclei cerebellar vermis Medulla Oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity acylphosphatase activity Cellular component extracellular exosome Biological process phosphate-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 97 66204 Ensembl ENSG00000119640 ENSMUSG00000008822 UniProt P07311 P56376 RefSeq (mRNA) NM_001107 NM_001302616 NM_001302617 NM_203488 NM_025421 NM_001364360 NM_001364361 RefSeq (protein) NP_001098 NP_001289545 NP_001289546 NP_079697 NP_001351289 NP_001351290 Location (UCSC) Chr 14: 75.05 – 75.07 Mb Chr 12: 85.32 – 85.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.

Function

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000119640 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000008822 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. Bibcode:1995FEBSL.367..145F. doi:10.1016/0014-5793(95)00553-L. PMID 7796909. S2CID 43318853.
6. Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. doi:10.1159/000015037. PMID 9730610. S2CID 46797997.
7. ^ "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".

External links

• Human ACYP1 genome location and ACYP1 gene details page in the UCSC Genome Browser.

Further reading

• Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. doi:10.1016/S0021-9258(18)99099-X. PMID 1645713.
• Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. doi:10.1111/j.1470-8744.1990.tb00112.x. PMID 2169259. S2CID 26999394.
• Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
• Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase" (PDF). The Journal of Biological Chemistry. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
• Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.

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