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ALPG
Identifiers
Aliases	ALPG, GCAP, ALPPL2, alkaline phosphatase, placental like 2, alkaline phosphatase, germ cell, ALPPL
External IDs	OMIM: 171810; MGI: 108009; HomoloGene: 129600; GeneCards: ALPG; OMA:ALPG - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.1 Start 232,406,844 bp End 232,410,714 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C5|1 44.05 cM Start 87,014,416 bp End 87,017,650 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad mucosa of colon placenta right uterine tube mucosa of transverse colon lower respiratory tract lung right lung endometrium Top expressed in morula morula blastocyst secondary oocyte perirhinal cortex entorhinal cortex choroid plexus of fourth ventricle primary oocyte CA3 field spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase activity catalytic activity hydrolase activity metal ion binding alkaline phosphatase activity Cellular component anchored component of membrane membrane extracellular region plasma membrane Biological process metabolism dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 251 11650 Ensembl ENSG00000163286 ENSMUSG00000026246 UniProt P10696 P24823 RefSeq (mRNA) NM_031313 NM_007433 RefSeq (protein) NP_112603 NP_031459 Location (UCSC) Chr 2: 232.41 – 232.41 Mb Chr 1: 87.01 – 87.02 Mb PubMed search
Wikidata
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Alkaline phosphatase, placental-like 2 is a protein that in humans is encoded by the ALPPL2 gene.

Function

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000163286 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026246 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: Alkaline phosphatase, placental-like 2".

External links

• Human ALPPL2 genome location and ALPPL2 gene details page in the UCSC Genome Browser.

Further reading

• Shigenari A, Ando A, Baba T, Yamamoto T, Katsuoka Y, Inoko H (November 1998). "Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning". Cancer Research. 58 (22): 5079–82. PMID 9823315.
• Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (August 1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proceedings of the National Academy of Sciences of the United States of America. 83 (15): 5597–601. Bibcode:1986PNAS...83.5597H. doi:10.1073/pnas.83.15.5597. PMC 386335. PMID 3461452.
• Jemmerson R, Shah N, Takeya M, Fishman WH (January 1985). "Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells". Cancer Research. 45 (1): 282–7. PMID 2578098.
• Shen LP, Liu H, Kan YW, Kam W (June 1988). "5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene". Nucleic Acids Research. 16 (12): 5694. doi:10.1093/nar/16.12.5694. PMC 336801. PMID 3387245.
• Lowe ME (February 1992). "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein". The Journal of Cell Biology. 116 (3): 799–807. doi:10.1083/jcb.116.3.799. PMC 2289307. PMID 1730777.
• Le Du MH, Stigbrand T, Taussig MJ, Menez A, Stura EA (March 2001). "Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity". The Journal of Biological Chemistry. 276 (12): 9158–65. doi:10.1074/jbc.M009250200. PMID 11124260.
• Fisken J, Leonard RC, Shaw G, Bowman A, Roulston JE (January 1989). "Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer". Journal of Clinical Pathology. 42 (1): 40–5. doi:10.1136/jcp.42.1.40. PMC 1141788. PMID 2921344.
• Ben-Arie A, Hagay Z, Ben-Hur H, Open M, Dgani R (September 1999). "Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 86 (1): 69–71. doi:10.1016/S0301-2115(99)00054-8. PMID 10471145.
• Goldstein DJ, Rogers C, Harris H (October 1982). "A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus". Clinica Chimica Acta; International Journal of Clinical Chemistry. 125 (1): 63–75. doi:10.1016/0009-8981(82)90046-8. PMID 6814793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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