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ARHGAP25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V89
Identifiers
Aliases	ARHGAP25, HEL-S-308, KAIA0053, Rho GTPase activating protein 25
External IDs	OMIM: 610587; MGI: 2443687; HomoloGene: 45507; GeneCards: ARHGAP25; OMA:ARHGAP25 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p13.3 Start 68,679,601 bp End 68,826,833 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D1 Start 87,435,527 bp End 87,510,241 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen lymph node monocyte bone marrow cells appendix periodontal fiber tonsil epithelium of colon Top expressed in granulocyte mesenteric lymph nodes spleen thymus bone marrow blood lumbar spinal ganglion stroma of bone marrow subcutaneous adipose tissue middle ear More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activator activity Cellular component cytosol phagocytic cup Biological process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction signal transduction phagocytosis, engulfment actin filament organization negative regulation of small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9938 232201 Ensembl ENSG00000163219 ENSMUSG00000030047 UniProt P42331 Q8BYW1 RefSeq (mRNA) NM_001007231 NM_001166276 NM_001166277 NM_014882 NM_001364819 NM_001364820 NM_001364821 NM_001037727 NM_001286610 NM_175476 RefSeq (protein) NP_001007232 NP_001159748 NP_001159749 NP_055697 NP_001351748 NP_001351749 NP_001351750 NP_001032816 NP_001273539 NP_780685 Location (UCSC) Chr 2: 68.68 – 68.83 Mb Chr 6: 87.44 – 87.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000163219 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030047 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Rho GTPase activating protein 25". Retrieved 2011-12-05.
6. Katoh M, Katoh M (August 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.

Further reading

• Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K (January 2010). "Mutation of ARHGAP9 in patients with coronary spastic angina". Journal of Human Genetics. 55 (1): 42–9. doi:10.1038/jhg.2009.120. PMID 19911011.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

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