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Acidic leucine-rich nuclear phosphoprotein 32 family member A

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Protein-coding gene in the species Homo sapiens

ANP32A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JE0, 2JE1, 4XOS

Identifiers
AliasesANP32A, C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32, acidic nuclear phosphoprotein 32 family member A
External IDsOMIM: 600832; MGI: 108447; HomoloGene: 133783; GeneCards: ANP32A; OMA:ANP32A - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)
Chromosome 15 (human)Genomic location for ANP32AGenomic location for ANP32A
Band15q23Start68,778,535 bp
End68,820,897 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for ANP32AGenomic location for ANP32A
Band9 B|9 33.68 cMStart62,248,575 bp
End62,286,094 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • monocyte

  • paraflocculus of cerebellum

  • middle frontal gyrus

  • rectum

  • blood

  • C1 segment

  • inferior ganglion of vagus nerve

  • granulocyte
Top expressed in
  • neural layer of retina

  • tail of embryo

  • genital tubercle

  • ventricular zone

  • granulocyte

  • maxillary prominence

  • dentate gyrus of hippocampal formation granule cell

  • mandibular prominence

  • superior frontal gyrus

  • migratory enteric neural crest cell
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8125

11737

Ensembl

ENSG00000140350

ENSMUSG00000032249

UniProt

P39687

O35381

RefSeq (mRNA)

NM_006305

NM_009672

RefSeq (protein)

NP_006296

NP_033802

Location (UCSC)Chr 15: 68.78 – 68.82 MbChr 9: 62.25 – 62.29 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene. It is one of the targets of an oncomiR, MIRN21.

Interactions

Acidic leucine-rich nuclear phosphoprotein 32 family member A has been shown to interact with MAP1B, TAF1A and Protein SET.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000140350Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032249Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen TH, Brody JR, Romantsev FE, Yu JG, Kayler AE, Voneiff E, Kuhajda FP, Pasternack GR (March 1997). "Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci". Mol Biol Cell. 7 (12): 2045–56. doi:10.1091/mbc.7.12.2045. PMC 276049. PMID 8970164.
  6. Ulitzur N, Humbert M, Pfeffer SR (June 1997). "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules". Proc Natl Acad Sci U S A. 94 (10): 5084–9. Bibcode:1997PNAS...94.5084U. doi:10.1073/pnas.94.10.5084. PMC 24635. PMID 9144194.
  7. "Entrez Gene: ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A".
  8. Opal P, Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y (September 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. ISSN 0021-9258. PMID 12807913.
  9. ^ Seo SB, McNamara P, Heo S, Turner A, Lane W S, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245.
  10. Fan Z, Beresford Paul J, Zhang Dong, Lieberman Judy (April 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973.

Further reading

External links

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