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Sulfoxone

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(Redirected from Aldesulfone sodium) Chemical compound Pharmaceutical compound
Sulfoxone
Skeletal formula of aldesulfone sodium
Space-filling model of the component ions of aldesulfone sodium
Clinical data
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Protein binding69%
MetabolismHepatic
Elimination half-life3 to 8 hours
Identifiers
IUPAC name
  • sulfonylphenyl] aminomethanesulfinic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H16N2Na2O6S3
Molar mass450.45 g·mol
3D model (JSmol)
SMILES
  • ..S(=O)CNc1ccc(cc1)S(=O)(=O)c2ccc(NCS()=O)cc2
InChI
  • InChI=1S/C14H16N2O6S3.2Na/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20;;/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20);;/q;2*+1/p-2
  • Key:AZBNFLZFSZDPQF-UHFFFAOYSA-L
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Sulfoxone or aldesulfone sodium is an anti-leprosy drug. It is also known as diasone. Sulfoxone sodium was introduced in Japan in 1948. Ernest Muir introduced it to Western use while serving as superintendent of the Chacachacare Leprosarium on Trinidad in the Caribbean.

References

  1. "Sulfoxone".
  2. Ozawa H, Maruyama Y (2002). "". Yakushigaku Zasshi. 37 (1): 76–83. PMID 12412600.
  3. Browne, Stanley George (1974), "Ernest Muir, C.M.G., C.I.E., M.D. (Edin.), F.R.C.S., LL.D. 1880–1974" (PDF), International Journal of Leprosy, vol. 42, no. 4, Bauru: International Leprosy Association, pp. 457–458, PMID 4617724.
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
Nucleic acid inhibitor
Rifamycins/
RNA polymerase inhibitor
Antifolates/DSI
ASA
Topoisomerase inhibitors/
quinolones
Protein synthesis inhibitor
Aminoglycosides
Oxazolidone
Polypeptide antibiotics
Cell envelope antibiotic
Peptidoglycan layer
Arabinogalactan layer
Mycolic acid layer
Other/unknown
Combinations
Antibacterials that inhibit nucleic acid (J01E, J01M)
Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-acting
Intermediate-acting
Long-acting
Other/ungrouped
Combinations
Other DHPS inhibitors
Quinolones
(inhibit bacterial
topoisomerase
and/or DNA gyrase,
thereby inhibiting
DNA replication)
1st generation
Fluoroquinolones
2nd generation
3rd generation
4th generation
Veterinary
Newer non-fluorinated
Related (DG)
Anaerobic DNA
inhibitors
Nitroimidazole derivatives
RNA synthesis
Rifamycins/
RNA polymerase
Lipiarmycins
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