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In enzymology, an alpha,alpha-trehalose-phosphate synthase (UDP-forming) (EC 2.4.1.15) is an enzyme that catalyzes the chemical reaction

UDP-glucose + D-glucose 6-phosphate ${\displaystyle \rightleftharpoons }$ UDP + alpha,alpha-trehalose 6-phosphate

Thus, the two substrates of this enzyme are UDP-glucose and D-glucose 6-phosphate, whereas its two products are UDP and alpha,alpha'-trehalose 6-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase. Other names in common use include UDP-glucose-glucose-phosphate glucosyltransferase, trehalosephosphate-UDP glucosyltransferase, UDP-glucose-glucose-phosphate glucosyltransferase, alpha,alpha-trehalose phosphate synthase (UDP-forming), phosphotrehalose-uridine diphosphate transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-P synthetase, transglucosylase, and uridine diphosphoglucose phosphate glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GZ5, 1UQT, and 1UQU.

References

• CABIB E, LELOIR LF (1958). "The biosynthesis of trehalose phosphate". J. Biol. Chem. 231 (1): 259–75. doi:10.1016/S0021-9258(19)77303-7. hdl:11336/135983. PMID 13538966.
• CANDY DJ, KILBY BA (1961). "The biosynthesis of trehalose in the locust fat body". Biochem. J. 78 (3): 531–6. doi:10.1042/bj0780531. PMC 1205371. PMID 13690400.
• LORNITZO FA, GOLDMAN DS (1964). "Purification and Properties of the Transglucosylase Inhibitor of Mycobacterium Tuberculosis". J. Biol. Chem. 239 (9): 2730–4. doi:10.1016/S0021-9258(18)93807-X. PMID 14216421.
• MURPHY TA, WYATT GR (1965). "The Enzymes of Glycogen and Trehalose Synthesis in Silk Moth Fat Body". J. Biol. Chem. 240 (4): 1500–8. doi:10.1016/S0021-9258(18)97463-6. PMID 14285483.

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