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Anziaic acid

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Carboxylate ester
Anziaic acid
Names
IUPAC name 4-(2,4-Dihydroxy-6-pentylbenzoyl)oxy-2-hydroxy-6-pentylbenzoic acid
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C24H30O7/c1-3-5-7-9-15-11-17(25)13-19(26)22(15)24(30)31-18-12-16(10-8-6-4-2)21(23(28)29)20(27)14-18/h11-14,25-27H,3-10H2,1-2H3,(H,28,29)Key: BEFYPHLCGVCBFF-UHFFFAOYSA-N
SMILES
  • CCCCCC1=C(C(=CC(=C1)O)O)C(=O)OC2=CC(=C(C(=C2)O)C(=O)O)CCCCC
Properties
Chemical formula C24H30O7
Molar mass 430.5 g/mol
Melting point 122 °C (252 °F; 395 K) dec
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Anziaic acid is a depside found in lichens. It gives a red reaction in the C test. The two phenolic rings have a pentyl side chain. It is an ester dimer of olivetolic acid.

Anziaic acid works as an antibacterial compound by inhibiting topoisomerase.

Production

Anziaic acid has been artificially produced from olivetolic acid by benzylation of the O-phenol positions, and then condensing with trifluoroacetic anhydride.

Properties

Anziaic acid is colourless. It can be dissolved in ethanol, ethanol-water mixture, or cyclohexane-benzene mixture.

Related

Perlatolic acid, dihydropicrolichenic acid, 2'-O-methylanziaic acid, 2-O-methylperlatolic acid, 2'-O-methylperlatolic and planaic acid are derivatives of anziaic acid, where a methyl group replaces a hydrogen in some of the hydroxy positions on the rings.

Occurrence

Anziaic acid is found in Parmeliaceae including Hypotrachyna, Stereocaulon, and Cetrelia,

References

  1. ^ Elix, J. A. (1974). "Synthesis of para-olivetol depsides". Australian Journal of Chemistry. 27 (8): 1767. doi:10.1071/CH9741767.
  2. ^ Cheng, Bokun; Cao, Shugeng; Vasquez, Victor; Annamalai, Thirunavukkarasu; Tamayo-Castillo, Giselle; Clardy, Jon; Tse-Dinh, Yuk-Ching (8 April 2013). "Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor". PLOS ONE. 8 (4): e60770. Bibcode:2013PLoSO...860770C. doi:10.1371/journal.pone.0060770. PMC 3620467. PMID 23593306.
  3. Kekuda, T.R Prashith; Lavanya, D .; Pooja, Rao (March 2019). "Lichens as promising resources of enzyme inhibitors: A review". Journal of Drug Delivery and Therapeutics. 9 (2S): 665–676. doi:10.22270/jddt.v9i2-s.2546.
  4. Ramaut, J. L.; Serusiaux, E.; Brouers, M.; Corvisier, M. (1978). "Lichen Acids of the Stereocaulon ramulosum Group in Central East Africa". The Bryologist. 81 (3): 415. doi:10.2307/3242244. JSTOR 3242244.
  5. Mark, Kristiina; Randlane, Tiina; Thor, Göran; Hur, Jae-Seoun; Obermayer, Walter; Saag, Andres (2019). "Lichen chemistry is concordant with multilocus gene genealogy in the genus Cetrelia (Parmeliaceae, Ascomycota)". Fungal Biology. 123 (2): 125–139. doi:10.1016/j.funbio.2018.11.013. PMID 30709518. S2CID 73439650.
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