Balestra may refer to:
- Balestra (surname), a list of people
- Palazzo Muti or Balestra, a 1644 townhouse in Rome
- Balestra, an Italian Navy Ariete-class torpedo boat of World War II
- In fencing, a type of forward step, usually followed by a lunge
- Balestra Capital Management, a hedge fund manager founded by James Melcher
- A synonym for Grignolino, a variety of wine grape
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