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C-C motif chemokine ligand 24

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Protein-coding gene in the species Homo sapiens
CCL24
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1EIG, 1EIH

Identifiers
AliasesCCL24, Ckb-6, MPIF-2, MPIF2, SCYA24, C-C motif chemokine ligand 24
External IDsOMIM: 602495; MGI: 1928953; HomoloGene: 2248; GeneCards: CCL24; OMA:CCL24 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for CCL24Genomic location for CCL24
Band7q11.23Start75,810,825 bp
End75,823,356 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for CCL24Genomic location for CCL24
Band5|5 G2Start135,598,791 bp
End135,601,903 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • rectum

  • spleen

  • mucosa of transverse colon

  • appendix

  • duodenum

  • lymph node

  • jejunal mucosa

  • right coronary artery

  • mucosa of sigmoid colon

  • upper lobe of left lung
Top expressed in
  • muscle of thigh

  • lip

  • white adipose tissue

  • esophagus

  • skeletal muscle tissue

  • jejunum

  • migratory enteric neural crest cell

  • subcutaneous adipose tissue

  • dermis

  • stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6369

56221

Ensembl

ENSG00000106178

ENSMUSG00000004814

UniProt

O00175

Q9JKC0

RefSeq (mRNA)

NM_002991
NM_001371193

NM_019577
NM_001356630

RefSeq (protein)

NP_002982
NP_001358122

NP_062523
NP_001343559

Location (UCSC)Chr 7: 75.81 – 75.82 MbChr 5: 135.6 – 135.6 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

C-C motif chemokine ligand 24 is a protein that in humans is encoded by the CCL24 gene.

Function

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000106178Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000004814Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: C-C motif chemokine ligand 24". Retrieved 2018-05-09.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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