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C-C motif chemokine ligand 3 like 3

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Protein-coding gene in the species Homo sapiens
CCL3L3
Identifiers
AliasesCCL3L3, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, SCYA3L, SCYA3L1, C-C motif chemokine ligand 3 like 3
External IDsOMIM: 609468; MGI: 98260; HomoloGene: 2242; GeneCards: CCL3L3; OMA:CCL3L3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for CCL3L3Genomic location for CCL3L3
Band17q12Start36,194,869 bp
End36,196,758 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for CCL3L3Genomic location for CCL3L3
Band11 C|11 51.04 cMStart83,538,670 bp
End83,540,181 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow

  • monocyte

  • bone marrow cells

  • testicle

  • gonad

  • lymph node

  • appendix

  • blood

  • granulocyte

  • spleen
Top expressed in
  • granulocyte

  • stroma of bone marrow

  • calvaria

  • spermatid

  • blood

  • dermis

  • secondary oocyte

  • thymus

  • islet of Langerhans

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

414062

20302

Ensembl

ENSG00000276085

ENSMUSG00000000982

UniProt

P16619

P10855

RefSeq (mRNA)

NM_001001437

NM_011337

RefSeq (protein)

NP_001001437
NP_066286

NP_035467

Location (UCSC)Chr 17: 36.19 – 36.2 MbChr 11: 83.54 – 83.54 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

C-C motif chemokine ligand 3 like 3 is a protein that in humans is encoded by the CCL3L3 gene.

Function

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000276085Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000000982Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: C-C motif chemokine ligand 3 like 3". Retrieved 2017-09-16.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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