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CCRL1

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Protein-coding gene in the species Homo sapiens
ACKR4
Identifiers
AliasesACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4
External IDsOMIM: 606065; MGI: 2181676; HomoloGene: 49474; GeneCards: ACKR4; OMA:ACKR4 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for ACKR4Genomic location for ACKR4
Band3q22.1Start132,597,270 bp
End132,618,967 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for ACKR4Genomic location for ACKR4
Band9|9 F1Start103,961,356 bp
End104,004,132 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • duodenum

  • ascending aorta

  • gallbladder

  • Descending thoracic aorta

  • subcutaneous adipose tissue

  • right coronary artery

  • skin of leg

  • Achilles tendon

  • skin of abdomen

  • Pituitary Gland
Top expressed in
  • lip

  • morula

  • choroid plexus of fourth ventricle

  • body of femur

  • umbilical cord

  • esophagus

  • calvaria

  • thymus

  • stroma of bone marrow

  • zone of skin
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51554

252837

Ensembl

ENSG00000129048

ENSMUSG00000079355

UniProt

Q9NPB9

Q924I3

RefSeq (mRNA)

NM_178445
NM_016557

NM_145700

RefSeq (protein)

NP_057641
NP_848540

NP_663746

Location (UCSC)Chr 3: 132.6 – 132.62 MbChr 9: 103.96 – 104 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000129048Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000079355Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Khoja H, Wang G, Ng CT, Tucker J, Brown T, Shyamala V (May 2000). "Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart". Gene. 246 (1–2): 229–38. doi:10.1016/S0378-1119(00)00076-7. PMID 10767544.
  6. ^ "Entrez Gene: CCRL1 chemokine (C-C motif) receptor-like 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytokine receptors
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamily
IL 17 family
Enzyme-linked receptor
Chemokine receptor modulators
CC
CCR1
CCR2
CCR3
CCR4
CCR5
CCR6
CCR7
CCR8
CCR9
CCR10
CCR11
Ungrouped
CXC
CXCR1
(IL-8Rα)
CXCR2
(IL-8Rβ)
CXCR3
CXCR4
CXCR5
CXCR6
CXCR7
C (XC)
XCR1
CX3C
CX3CR1
Others
CCBP2
CMKLR1
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