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CGP 52608

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CGP 52608
Names
IUPAC name 3-Methyl-1-thiourea
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
InChI
  • InChI=1/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-Key: DDYJDIHOSRTMSE-FLIBITNWBI
SMILES
  • S=C(N\N=C1/SCC(=O)N1C\C=C)NC
Properties
Chemical formula C8H12N4OS2
Molar mass 244.33 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

CGP 52608 is a selective ligand of the RAR-related orphan receptor alpha. It has been used as a biochemical tool to investigate nuclear and membrane signaling of melatonin. CGP 52608 has also been reported to possess antiarthritic activity. The pharmaceutical company Novartis brought it to clinical trials for rheumatoid arthritis, but development was discontinued in 2006.

CGP 52608 contains a thiazolinidinedione group.

References

  1. ^ Wiesenberg I, Missbach M, Kahlen JP, Schräder M, Carlberg C (February 1995). "Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand". Nucleic Acids Res. 23 (3): 327–33. doi:10.1093/nar/23.3.327. PMC 306679. PMID 7885826.
  2. Missbach M, Jagher B, Sigg I, Nayeri S, Carlberg C, Wiesenberg I (June 1996). "Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor/retinoid acid receptor-related orphan receptor alpha with potent antiarthritic activity". J. Biol. Chem. 271 (23): 13515–22. doi:10.1074/jbc.271.23.13515. PMID 8662835.
  3. "CGP 52608". Adis Insight.
  4. Winczyk, K; Pawlikowski, M; Karasek, M (Sep 2001). "Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer". J Pineal Res. 31 (2): 179–82. doi:10.1034/j.1600-079x.2001.310213.x. PMID 11555175. S2CID 6461798.

External links

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