Chain of Rocks refers to a region of exposed bedrock in a riverbed. It may refer to multiple locations near the Illinois-Missouri border:
- Chain of Rocks, Missouri, a small town northwest of St. Louis
- The old Chain of Rocks Bridge, now restricted to pedestrian and bicycle traffic
- The New Chain of Rocks Bridge, its vehicular replacement
- The Chain of Rocks Lock, a river-navigational structure nearby
- The former Chain of Rocks Amusement Park site nearby
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