Charles-Édouard is a masculine given name. Notable people with the name include:
- Charles-Édouard Brown-Séquard (1817–1894), Mauritian-born physiologist and neurologist
- Charles-Édouard Campeau (1916–1992), Canadian engineer
- Charles-Édouard Coridon (born 1973), French-Martiniquais football midfielder
- Charles-Édouard D'Astous [fr; fi; sv] (born 1998), Canadian Ice Hockey player
- Charles-Édouard Houde (1823–1912), Canadian politician
- Charles-Édouard Lefebvre (1843–1917), French composer
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