A chondroprotective compound is a specific compound or chemical that delays progressive joint space narrowing characteristic of arthritis and improves the biomechanics of articular joints by protecting chondrocytes. These agents perform various functions, such as:
- Stimulating chondrocyte synthesis of collagen and proteoglycans
- Enhancing synoviocyte production of hyaluronan
- Inhibiting cartilage degradation
- Preventing fibrin formation in the vasculature
Chondroprotective agents can include both endogenous and synthetic chemicals. Endogenous molecules include hyaluronic acid, glucosamine, and chondroitin sulfate.
References
- Felson, David T.; Kim, Young-Jo (2007). "The Futility of Current Approaches to Chondroprotection". Arthritis & Rheumatism. 56 (5): 1378–1383. doi:10.1002/art.22526. PMID 17469094.
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