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Chronic fatigue may refer to:

• Chronic fatigue, a long-term state of physical or mental exhaustion, a symptom of many chronic illnesses and of idiopathic chronic fatigue
• Myalgic encephalomyelitis/chronic fatigue syndrome, a discrete chronic medical condition characterized by post-exertional malaise, symptoms of profound intensity including fatigue, pain, and cognitive impairment and usually caused or precipitated by a systemic infection.

• Disambiguation pages