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CSF2RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8
Identifiers
Aliases	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDs	OMIM: 138981; MGI: 1339760; HomoloGene: 339; GeneCards: CSF2RB; OMA:CSF2RB - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 36,913,628 bp End 36,940,439 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 37.22 cM Start 78,166,707 bp End 78,189,921 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood periodontal fiber decidua appendix epithelium of nasopharynx mononuclear cell monocyte bone marrow bone marrow cells testicle Top expressed in mesenteric lymph nodes granulocyte stroma of bone marrow subcutaneous adipose tissue lactiferous gland tibiofemoral joint muscle of thigh blood spleen Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-3 receptor activity interleukin-5 receptor activity protein binding cytokine receptor activity protein tyrosine kinase activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane granulocyte macrophage colony-stimulating factor receptor complex intracellular anatomical structure Biological process respiratory gaseous exchange by respiratory system MAPK cascade signal transduction response to lipopolysaccharide peptidyl-tyrosine phosphorylation interleukin-5-mediated signaling pathway cellular response to interleukin-3 interleukin-3-mediated signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1439 12984 Ensembl ENSG00000100368 ENSMUSG00000071714 UniProt P32927 P26954 RefSeq (mRNA) NM_000395 NM_001287389 NM_007781 RefSeq (protein) NP_000386 NP_001274318 NP_031807 Location (UCSC) Chr 22: 36.91 – 36.94 Mb Chr 15: 78.17 – 78.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

• GM-CSF receptor
• IL-3 receptor
• IL-5 receptor.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

• Cytokine+Receptor+Common+beta+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.

• Genes on human chromosome 22