Conococheague may refer to some locations in the eastern United States, as well as a geological formation that outcrops in the same area:
- Conococheague Creek, a tributary of the Potomac River
- Conococheague Mountain, a ridge in Perry County, Pennsylvania
- Wilson-Conococheague, Maryland, a combination of the communities of Wilson and Conococheague
- Conococheague Formation, a geologic formation
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