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CYTL1
Identifiers
Aliases	CYTL1, C17, C4orf4, cytokine like 1
External IDs	OMIM: 607930; MGI: 2684993; HomoloGene: 10254; GeneCards: CYTL1; OMA:CYTL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.2 Start 5,014,586 bp End 5,019,458 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 37,892,863 bp End 37,897,164 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia trachea ascending aorta Descending thoracic aorta cartilage tissue trabecular bone canal of the cervix popliteal artery tibial arteries ectocervix Top expressed in skin of external ear intercostal muscle interventricular septum ankle basilar part of occipital bone aorta laryngeal cartilages right lung lobe stria vascularis aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding Cellular component extracellular region extracellular space Biological process inner ear development chondroitin sulfate proteoglycan biosynthetic process positive regulation of DNA-binding transcription factor activity cartilage homeostasis chondrocyte differentiation signal transduction positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54360 231162 Ensembl ENSG00000170891 ENSMUSG00000062329 UniProt Q9NRR1 A1E5L0 RefSeq (mRNA) NM_018659 NM_001081106 RefSeq (protein) NP_061129 NP_001074575 Location (UCSC) Chr 4: 5.01 – 5.02 Mb Chr 5: 37.89 – 37.9 Mb PubMed search
Wikidata
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Cytokine-like protein 1 (also protein C17) is a protein that in humans is encoded by the CYTL1 gene.

Function

Protein C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 surface marker. Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells. CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000170891 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062329 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Cytokine-like 1".
6. ^ Liu X, Rapp N, Deans R, Cheng L (May 2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics. 65 (3): 283–92. doi:10.1006/geno.2000.6170. PMID 10857752.
7. Ai Z, Jing W, Fang L (2016). "Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation". PLOS ONE. 11 (1): e0147424. Bibcode:2016PLoSO..1147424A. doi:10.1371/journal.pone.0147424. PMC 4723121. PMID 26800213.

Further reading

• Deng X, Zhao HS, Peng Z, Deng WW, Li N, Guo S, Shi TP (April 2011). "". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (2): 168–72. PMID 21503106.
• Tomczak A, Pisabarro MT (April 2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". Proteins. 79 (4): 1277–92. doi:10.1002/prot.22963. PMID 21322034. S2CID 24312749.
• Chao C, Joyce-Shaikh B, Grein J, Moshrefi M, Raoufi F, Laface DM, McClanahan TK, Bourne PA, Pierce RH, Gorman DM, Pflanz S (2011). "C17 prevents inflammatory arthritis and associated joint destruction in mice". PLOS ONE. 6 (7): e22256. Bibcode:2011PLoSO...622256C. doi:10.1371/journal.pone.0022256. PMC 3143151. PMID 21799806.
• Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW (March 2012). "ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior". Chinese Medical Journal. 125 (6): 1127–34. PMC 4174677. PMID 22613542.
• Kwon YJ, Lee SJ, Koh JS, Kim SH, Lee HW, Kang MC, Bae JB, Kim YJ, Park JH (January 2012). "Genome-wide analysis of DNA methylation and the gene expression change in lung cancer". Journal of Thoracic Oncology. 7 (1): 20–33. doi:10.1097/JTO.0b013e3182307f62. PMID 22011669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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