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DAOA-AS1
Identifiers
Aliases	DAOA-AS1, DAOA-AS, DAOAAS, G30, DAOA antisense RNA 1
External IDs	OMIM: 607415; GeneCards: DAOA-AS1; OMA:DAOA-AS1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q33.2|13q34 Start 105,459,055 bp End 105,505,681 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell gonad upper lobe of left lung left testis n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 282706 n/a Ensembl ENSG00000232307 n/a UniProt n a n/a RefSeq (mRNA) NM_172368 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 13: 105.46 – 105.51 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

In molecular biology, DAOA-AS1, DAOA antisense RNA 1 (non-protein coding), (formerly known as G30), is a human gene encoding a long non-coding RNA. It was originally identified in a screen for genes associated with schizophrenia. It is also associated with bipolar disorder and other psychiatric phenotypes. It may regulate the expression of the DAOA gene.

See also

• D-amino acid oxidase activator
• Long non-coding RNA

References

1. ^ GRCh38: Ensembl release 89: ENSG00000232307 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. (Oct 2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13675–13680. Bibcode:2002PNAS...9913675C. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586.
4. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (May 2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series". American Journal of Human Genetics. 72 (5): 1131–1140. doi:10.1086/374822. PMC 1180266. PMID 12647258.
5. Abou Jamra R, Schmael C, Cichon S, Rietschel M, Schumacher J, Nöthen MM (Oct 2006). "The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?". Schizophrenia Bulletin. 32 (4): 599–608. doi:10.1093/schbul/sbl028. PMC 2632259. PMID 16914640.

Further reading

• Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (May 2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series". American Journal of Human Genetics. 72 (5): 1131–1140. doi:10.1086/374822. PMC 1180266. PMID 12647258.
• Wang X, He G, Gu N, Yang J, Tang J, Chen Q, Liu X, Shen Y, Qian X, Lin W, Duan Y, Feng G, He L (Jul 2004). "Association of G72/G30 with schizophrenia in the Chinese population". Biochemical and Biophysical Research Communications. 319 (4): 1281–1286. doi:10.1016/j.bbrc.2004.05.119. PMID 15194506.
• Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, Bernstein J, Bening-Abu-Shach U, Ben-Asher E, Lancet D, Ritsner M, Navon R (Aug 2004). "Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis". Biological Psychiatry. 56 (3): 169–176. doi:10.1016/j.biopsych.2004.04.006. PMID 15271585. S2CID 36460604.
• Schumacher J, Abou Jamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun S, Schulze TG, Rietschel M, Illig T, Propping P, Cichon S, Deckert J, Nöthen MM (May 2005). "Investigation of the DAOA/G30 locus in panic disorder". Molecular Psychiatry. 10 (5): 428–429. doi:10.1038/sj.mp.4001598. PMID 15477870.
• Britten RJ (Nov 2004). "Coding sequences of functioning human genes derived entirely from mobile element sequences". Proceedings of the National Academy of Sciences of the United States of America. 101 (48): 16825–16830. Bibcode:2004PNAS..10116825B. doi:10.1073/pnas.0406985101. PMC 534736. PMID 15546984.
• Zou F, Li C, Duan S, Zheng Y, Gu N, Feng G, Xing Y, Shi J, He L (Mar 2005). "A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population". Schizophrenia Research. 73 (2–3): 257–261. doi:10.1016/j.schres.2004.01.015. PMID 15653269. S2CID 31923687.
• Mulle JG, McDonough JA, Chowdari KV, Nimgaonkar V, Chakravarti A (May 2005). "Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families". Molecular Psychiatry. 10 (5): 429–431. doi:10.1038/sj.mp.4001639. PMID 15738936.
• Ma J, Qin W, Wang XY, Guo TW, Bian L, Duan SW, Li XW, Zou FG, Fang YR, Fang JX, Feng GY, Gu NF, St Clair D, He L (May 2006). "Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations". Molecular Psychiatry. 11 (5): 479–487. doi:10.1038/sj.mp.4001788. PMID 16402132.
• Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ (Jul 2006). "Family-based association study between G72/G30 genetic polymorphism and schizophrenia". NeuroReport. 17 (10): 1067–1069. doi:10.1097/01.wnr.0000224763.61959.26. PMID 16791105. S2CID 2199301.
• Li D, He L (Feb 2007). "G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies". Genetics. 175 (2): 917–922. doi:10.1534/genetics.106.061796. PMC 1800627. PMID 17179078.
• Yue W, Liu Z, Kang G, Yan J, Tang F, Ruan Y, Zhang J, Zhang D (Dec 2006). "Association of G72/G30 polymorphisms with early-onset and male schizophrenia". NeuroReport. 17 (18): 1899–1902. CiteSeerX 10.1.1.612.6655. doi:10.1097/WNR.0b013e3280102ed4. PMID 17179866. S2CID 14178731.

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