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DRG2

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Protein-coding gene in the species Homo sapiens
DRG2
Identifiers
AliasesDRG2, developmentally regulated GTP binding protein 2
External IDsOMIM: 602986; MGI: 1342307; HomoloGene: 1061; GeneCards: DRG2; OMA:DRG2 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for DRG2Genomic location for DRG2
Band17p11.2Start18,087,892 bp
End18,107,970 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for DRG2Genomic location for DRG2
Band11 B2|11 37.81 cMStart60,345,417 bp
End60,359,580 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • right lobe of liver

  • anterior pituitary

  • apex of heart

  • body of uterus

  • gastrocnemius muscle

  • right ovary

  • right lobe of thyroid gland

  • left ovary

  • canal of the cervix
Top expressed in
  • otic vesicle

  • morula

  • neural layer of retina

  • internal carotid artery

  • otic placode

  • external carotid artery

  • saccule

  • tail of embryo

  • epiblast

  • ventricular zone
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1819

13495

Ensembl

ENSG00000108591

ENSMUSG00000020537

UniProt

P55039

Q9QXB9

RefSeq (mRNA)

NM_001388
NM_001330144

NM_021354

RefSeq (protein)

NP_001317073
NP_001379

NP_067329

Location (UCSC)Chr 17: 18.09 – 18.11 MbChr 11: 60.35 – 60.36 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000108591Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020537Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 274–5. doi:10.1159/000134741. PMID 9605870.
  6. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (Nov 1994). "A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts". J Biol Chem. 269 (41): 25447–53. doi:10.1016/S0021-9258(18)47271-7. PMID 7929244.
  7. ^ "Entrez Gene: DRG2 developmentally regulated GTP binding protein 2".

Further reading


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