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In enzymology, a dihydrobunolol dehydrogenase (EC 1.1.1.160) is an enzyme that catalyzes the chemical reaction

(+/−)-5--1,2,3,4-tetrahydro-1- naphthol + NADP ${\displaystyle \rightleftharpoons }$ (+/−)-5--3,4-dihydro-1(2H)- naphthalenone + NADPH + H

The three substrates of this enzyme are -1,2,3,4-tetrahydro-1-naphthol]], and NADP, whereas its 4 products are -3,4-dihydro-1(2H)-]], naphthalenone, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (+/−)-5--1,2,3,4-tetrahydro-1-naphthol:NADP oxidoreductase. This enzyme is also termed bunolol reductase.

References

• Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2 (2): 191–202. doi:10.3109/00498257209111050. PMID 4560367.
• Leinweber FJ, Greenough RC, Schwender CF, Kaplan HR, Di Carlo FJ (1972). "Bunolol metabolism by cell-free preparations of human liver: biosynthesis of dihydrobunolol". Xenobiotica. 2 (2): 191–202. doi:10.3109/00498257209111050. PMID 4560367.

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