Don't Give Up the Ship may refer to:
- "Don't give up the ship," the dying command of James Lawrence in 1813 aboard USS Chesapeake (1799)
- "Don't Give Up the Ship," words on the battle flag of Oliver Hazard Perry in 1813 aboard USS Niagara (1813)
- Don't Give Up the Ship (film), a 1959 comedy
- Don't Give Up the Ship (game), a set of rules for naval war games
- "Don't Give Up the Ship," the motto of the Hudson High School Explorers
See also
- Don't Give Up the Sheep, a 1953 Chuck Jones cartoon
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