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ERLIN2
Identifiers
Aliases	ERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
External IDs	OMIM: 611605; MGI: 2387215; HomoloGene: 5193; GeneCards: ERLIN2; OMA:ERLIN2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p11.23 Start 37,736,601 bp End 37,758,422 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A2 Start 27,513,289 bp End 27,530,356 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus renal medulla Achilles tendon islet of Langerhans parotid gland germinal epithelium mucosa of paranasal sinus bronchial epithelial cell kidney tubule caput epididymis Top expressed in spermatocyte otolith organ utricle Epithelium of choroid plexus right kidney vestibular membrane of cochlear duct decidua superior cervical ganglion gastrula proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding protein tyrosine kinase activity ubiquitin protein ligase binding Cellular component integral component of membrane membrane raft membrane endoplasmic reticulum plasma membrane endoplasmic reticulum membrane cytosol protein-containing complex Biological process SREBP signaling pathway steroid metabolic process cholesterol metabolic process negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process lipid metabolism ubiquitin-dependent ERAD pathway peptidyl-tyrosine phosphorylation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11160 244373 Ensembl ENSG00000147475 ENSMUSG00000031483 UniProt O94905 Q8BFZ9 RefSeq (mRNA) NM_001003790 NM_001003791 NM_007175 NM_001362878 NM_001362880 NM_153592 NM_001364476 NM_001364477 NM_001379175 NM_001379176 NM_001379177 NM_001379178 RefSeq (protein) NP_001003790 NP_001003791 NP_009106 NP_001349807 NP_001349809 NP_705820 NP_001351405 NP_001351406 NP_001366104 NP_001366105 NP_001366106 NP_001366107 NP_001391043 NP_001391044 NP_001391045 Location (UCSC) Chr 8: 37.74 – 37.76 Mb Chr 8: 27.51 – 27.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000147475 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031483 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. S2CID 39559998.
6. Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872.
7. Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.
8. "Entrez Gene: ERLIN2 ER lipid raft associated 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ (Jul 2007). "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells". The Journal of Biological Chemistry. 282 (28): 20104–15. doi:10.1074/jbc.M701862200. PMID 17502376.

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