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Edna Cukierman

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Mexican biochemist and academic
Eti Cukierman
Cukierman in a Congressionally Directed Medical Research Programs (CDMRP) photo, 2018
BornEdna Cukierman
Mexico City
Alma materTechnion – Israel Institute of Technology
Scientific career
FieldsTumor microenvironment
Cancer associated fibroblasts
Extracellular matrix
Pancreatic cancer
Desmoplasia
InstitutionsNational Institute of Dental and Craniofacial Research
Fox Chase Cancer Center
ThesisMolecular characterization of an ARF directed GTPase activating protein (1997)
Doctoral studentsJaye Gardiner
Websitewww.foxchase.org/edna-cukierman Edit this at Wikidata

Edna "Eti" Cukierman is a Mexican biochemist who is a professor at the Fox Chase Cancer Center. She serves as co-director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute. Her research investigates pancreatic cancer and the tumor microenvironment.

Early life and education

Cukierman was born in Mexico City. She emigrated to Israel in 1986. She joined Technion – Israel Institute of Technology for her doctoral research, where she studied ARF directed GTPase.

Research and career

After her PhD, Cukierman was awarded a postdoctoral fellowship in 1997, and joined the National Institute of Dental and Craniofacial Research. She developed a multilayered fibroblastic cell-derived extracellular matrix, which became widely used in biomaterials research.

Cukierman joined the Fox Chase Cancer Center in 2002. She studies pancreatic cancer, with a specific focus on the tumor microenvironment and the identification of strategies that can change the tumor microenvironment. Desmoplasia, which is the growth of connective tissue, shows similarities to wound healing pathologies (e.g. chronic inflammation). She believes it will be possible to stall the growth of tumors by transforming the microenvironment into one which harnesses anti-tumor functions.

In 2005, Cukierman demonstrated that desmoplastic extracellular matrices could induce a myofibroblastic phenotype on naïve fibroblastic cells. This work involved the realization of a human mimetic three-dimensional stroma system, which allowed Cukierman to understand the extracellular factors that determine the function of fibroblasts. Through multi-cellular culturing, Cukierman has shown how cancer-associated fibroblasts impart immunosuppressive influences, communicate and provide nutrition to cancer cells. She identified that cancer communication involved the TGF beta signaling pathway, extracellular matrix and integrin signalling pathway and the reorganization of cytoskeletal elements. She demonstrated that the glutamatergic presynaptic protein Netrin G1 promoted tumorgenesis by providing nutritional support and immunity to cancer-associated fibroblasts. She has shown that anti-Netrin G1 antibodies can halt tumorgenesis.

Cukierman joined the American Gastroenterological Association in 2010. At the time, this was considered novel because the association is mainly a medical association, and Cukierman is not a physician. In 2017, she established the Marvin and Concetta Greenberg Pancreatic Cancer Institute.

Awards and honors

Academic service

Cukierman has supported the development of early career researchers, and has developed a philosophy around teaching and mentoring. She is a member of the American Cancer Society, and on the editorial board of Matrix Biology.

Selected publications

  • Taking cell-matrix adhesions to the third dimension
  • Modeling tissue morphogenesis and cancer in 3D
  • A framework for advancing our understanding of cancer-associated fibroblasts

References

  1. ^ Edna Cukierman publications indexed by Google Scholar Edit this at Wikidata
  2. Edna Cukierman publications from Europe PubMed Central
  3. ^ "Edna Cukierman Elected to Council of the American Society for Matrix Biology". foxchase.org. 2020-01-07. Retrieved 2022-11-06.
  4. "איפיון וניקוי של חלבון ממברנת הפלסמה של הטפיל ליישמניה דונובני | WorldCat.org". worldcat.org. Retrieved 2022-11-06.
  5. "Molecular characterization of an ARF directed GTPase activating protein | WorldCat.org". worldcat.org. Retrieved 2022-11-06.
  6. ^ "3-D Vision Brings New Perspectives". American Association for Cancer Research (AACR). Retrieved 2022-11-06.
  7. Madhusoodanan, Jyoti (2019-02-26). "Matrix mimics shape cell studies". Nature. 566 (7745): 563–565. Bibcode:2019Natur.566..563M. doi:10.1038/d41586-019-00681-1. PMID 30809069. S2CID 71147041.
  8. ^ "Cukierman Named Fellow of the American Gastroenterological Association". foxchase.org. 2020-02-14. Retrieved 2022-11-06.
  9. ^ "Edna (Eti) Cukierman". foxchase.org. 2015-11-03. Retrieved 2022-11-06.
  10. "Exploring how a tumour's environment helps it grow". Worldwide Cancer Research. Retrieved 2022-11-06.
  11. ^ "Fox Chase Researcher Receives Grant for Study of Biology of Pancreatic Cancer". foxchase.org. 2020-01-27. Retrieved 2022-11-06.
  12. ^ Amatangelo, Michael D.; Bassi, Daniel E.; Klein-Szanto, Andrés J. P.; Cukierman, Edna (August 2005). "Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts". The American Journal of Pathology. 167 (2): 475–488. doi:10.1016/S0002-9440(10)62991-4. ISSN 0002-9440. PMC 1603576. PMID 16049333.
  13. Franco-Barraza, Janusz; Francescone, Ralph; Luong, Tiffany; Shah, Neelima; Madhani, Raj; Cukierman, Gil; Dulaimi, Essel; Devarajan, Karthik; Egleston, Brian L; Nicolas, Emmanuelle; Katherine Alpaugh, R; Malik, Ruchi; Uzzo, Robert G; Hoffman, John P; Golemis, Erica A (2017-01-31). Ivaska, Johanna (ed.). "Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence". eLife. 6: e20600. doi:10.7554/eLife.20600. ISSN 2050-084X. PMC 5283834. PMID 28139197.
  14. Francescone, Ralph; Barbosa Vendramini-Costa, Débora; Franco-Barraza, Janusz; Wagner, Jessica; Muir, Alexander; Lau, Allison N.; Gabitova, Linara; Pazina, Tatiana; Gupta, Sapna; Luong, Tiffany; Rollins, Dustin; Malik, Ruchi; Thapa, Roshan J.; Restifo, Diana; Zhou, Yan (2021-02-01). "Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression". Cancer Discovery. 11 (2): 446–479. doi:10.1158/2159-8290.CD-20-0775. ISSN 2159-8274. PMC 7858242. PMID 33127842.
  15. "Edna Cukierman: How Fox Chase is Becoming a Hub for Pancreatic Research". foxchase.org. 2018-07-19. Retrieved 2022-11-06.
  16. "Edna Cukierman". Nikon's Small World. Retrieved 2022-11-06.
  17. "Pollen grains | 2005 Photomicrography Competition". Nikon's Small World. Retrieved 2022-11-06.
  18. "Officers". asmb.net. Retrieved 2022-11-06.
  19. "Dr. Edna Cukierman, PhD - Editorial Board - Matrix Biology - Journal - Elsevier". journals.elsevier.com. Retrieved 2022-11-06.
  20. Cukierman E; Pankov R; Stevens DR; Yamada KM (23 November 2001). "Taking cell-matrix adhesions to the third dimension". Science. 294 (5547): 1708–12. Bibcode:2001Sci...294.1708C. doi:10.1126/SCIENCE.1064829. ISSN 0036-8075. PMID 11721053. Wikidata Q29615214.
  21. Kenneth M Yamada; Edna Cukierman (1 August 2007). "Modeling tissue morphogenesis and cancer in 3D". Cell. 130 (4): 601–610. doi:10.1016/J.CELL.2007.08.006. ISSN 0092-8674. PMID 17719539. Wikidata Q34667330.
  22. Erik Sahai; Igor Astsaturov; Edna Cukierman; et al. (24 January 2020). "A framework for advancing our understanding of cancer-associated fibroblasts". Nature Reviews Cancer. 20 (3): 174–186. doi:10.1038/S41568-019-0238-1. ISSN 1474-175X. PMC 7046529. PMID 31980749. Wikidata Q92932998.
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