Empalme (Spanish: "junction", "splice", "union") may refer to
- Places
- Empalme, Sonora, city in northwestern Mexico
- Empalme Villa Constitución, town in the Argentine province of Santa Fe
- El Empalme, town in the Ecuadorian province of Guayas
- Empalme Escobedo, in the Mexican state of Guanajuato
- Empalme Nicolich, in Uruguay
- Empalme Olmos, in Uruguay
- Other
- Empalme (food), tortilla sandwich originating in the Mexican state of Nuevo León
- Empalme (Madrid Metro), station on Line 5 of the Madrid Metro
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