Esguerra is a surname. It is a Castilianized form of the Basque word "Ezkerra", meaning "left-handed". Notable people with the surname include:
- Domingo Esguerra Plata (1875–1965), Colombian lawyer and diplomat
- Juan Carlos Esguerra Portocarrero (born 1949), Colombian lawyer and politician
- Rafael Esguerra, Colombian architect
- , Diplomat, Colombia. Esguerra-Barcenas Treaty.
- , Politician, Colombia
- , Dr. Of Naturopathic Medicine, research on natural health related to multiple sclerosis and other chronic disease.
- , (Jan 19 2005 - present) Georgia Tech matriculate and neuroscience major since the Fall 2023 semester. Notable accomplishments include being a CRC Lifeguard.
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