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TVP23B

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(Redirected from FAM18B1) Protein-coding gene in the species Homo sapiens
TVP23B
Identifiers
AliasesTVP23B, FAM18B, FAM18B1, NPD008, YDR084C, CGI-148, trans-golgi network vesicle protein 23 homolog B (S. cerevisiae), trans-golgi network vesicle protein 23 homolog B
External IDsMGI: 1914760; HomoloGene: 128511; GeneCards: TVP23B; OMA:TVP23B - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)
Chromosome 17 (human)Genomic location for TVP23BGenomic location for TVP23B
Band17p11.2Start18,781,111 bp
End18,806,714 bp
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)
Chromosome 11 (mouse)Genomic location for TVP23BGenomic location for TVP23B
Band11|11 B2Start62,770,281 bp
End62,807,606 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • Achilles tendon

  • stromal cell of endometrium

  • mucosa of esophagus

  • gonad

  • olfactory zone of nasal mucosa

  • body of pancreas

  • rectum

  • anterior pituitary

  • gallbladder
Top expressed in
  • otolith organ

  • utricle

  • vestibular sensory epithelium

  • superior cervical ganglion

  • lobe of prostate

  • olfactory epithelium

  • parotid gland

  • seminal vesicula

  • ciliary body

  • submandibular gland
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

51030

67510

Ensembl

ENSG00000171928

ENSMUSG00000014177

UniProt

Q9NYZ1

Q9D8T4

RefSeq (mRNA)
NM_016078
NM_001316919
NM_001316920
NM_001316921
NM_001316922

NM_001316923
NM_001316924

NM_026210
NM_001356520
NM_001356521

RefSeq (protein)
NP_001303848
NP_001303849
NP_001303850
NP_001303851
NP_001303852

NP_001303853
NP_057162

NP_080486
NP_001343449
NP_001343450

Location (UCSC)Chr 17: 18.78 – 18.81 MbChr 11: 62.77 – 62.81 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Golgi apparatus membrane protein TVP23 homolog B is a protein encoded by the gene TVP23B.

This gene has two paralog in the human genome, TVP23C, which is located on chromosome 17 at 17p12, and TVP23A, which is located on chromosome 16. The duplication appears to have appeared after the MRCA of humans and apes. This gene has homologs in eukaryotes as far back as Trichoplax.

Gene

TVP23B is highly conserved in chordates and also shows conservation in eukaryotes, including fungi and plants. The most common mRNA has 7 exons.

Protein

This gene encode a protein of 205 amino acids in length and a predicted molecular weight of 23.57 kDa. This protein is predicted to have an isoelectric point of 8.62. It contains a domain of unknown function, DUF846, and a predicted phosphoserine site. It is a multipass transmembrane protein and a member of the FAM18/TVP23 superfamily.

TVP23B appears to be ubiquitously expressed in all tissues, health states, and developmental stages to some level. There is also notable expression in bladder tissue.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000171928 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000014177 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Pre-computed BLAST results for LOC51030 [Homo sapiens]". BLINK ("BLAST Link"). National Center for Biotechnology Information, United States National Institutes of Health.
  6. "UniProt Database".
  7. "EST Profile Database".
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