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FDX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y5C
Identifiers
Aliases	FDX2, ferredoxin 2, FDX1L, ferredoxin 1 like, MEOAL
External IDs	OMIM: 614585; MGI: 1915415; HomoloGene: 31955; GeneCards: FDX2; OMA:FDX2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,310,045 bp End 10,316,015 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 21,067,520 bp End 21,073,614 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex anterior cingulate cortex Brodmann area 9 right frontal lobe superior frontal gyrus nucleus accumbens Hypothalamus substantia nigra Temporal Lobe hippocampus proper Top expressed in quadriceps femoris muscle white adipose tissue bone marrow muscle of thigh striatum of neuraxis muscle tissue proximal tubule embryo skeletal muscle tissue superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function iron-sulfur cluster binding protein binding metal ion binding 2 iron, 2 sulfur cluster binding electron transfer activity Cellular component mitochondrial matrix mitochondrion Biological process C21-steroid hormone biosynthetic process sterol metabolic process small molecule metabolic process electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112812 68165 Ensembl ENSG00000267673 ENSMUSG00000079677 UniProt Q6P4F2 Q9CPW2 RefSeq (mRNA) NM_080665 NM_001031734 NM_001397406 NM_001039824 RefSeq (protein) NP_001026904 NP_001034913 Location (UCSC) Chr 19: 10.31 – 10.32 Mb Chr 9: 21.07 – 21.07 Mb PubMed search
Wikidata
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Ferredoxin 2 is a protein that in humans is encoded by the FDX2 gene. It participates in heme A synthesis and iron-sulphur protein synthesis.

Mutations in FDX2 cause mitochondrial myopathy.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000267673 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000079677 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ferredoxin 2".
6. Spiegel R, Saada A, Halvardson J, Soiferman D, Shaag A, Edvardson S, Horovitz Y, Khayat M, Shalev SA, Feuk L, Elpeleg O (July 2014). "Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy". European Journal of Human Genetics. 22 (7): 902–6. doi:10.1038/ejhg.2013.269. PMC 4060119. PMID 24281368.

Further reading

• Sheftel AD, Stehling O, Pierik AJ, Elsässer HP, Mühlenhoff U, Webert H, Hobler A, Hannemann F, Bernhardt R, Lill R (June 2010). "Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (26): 11775–80. Bibcode:2010PNAS..10711775S. doi:10.1073/pnas.1004250107. PMC 2900682. PMID 20547883.

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