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FEM-1689

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Chemical compound Pharmaceutical compound
FEM-1689
Identifiers
IUPAC name
  • 3--9-azatricyclododeca-2(7),3,5-trien-9-yl]propan-1-ol
CAS Number
PubChem CID
Chemical and physical data
FormulaC21H22F3NO
Molar mass361.408 g·mol
3D model (JSmol)
SMILES
  • FC(F)(F)c1ccc(cc1)c1cc2c(cc1)C1CC2N(CC1)CCCO
InChI
  • InChI=1S/C21H22F3NO/c22-21(23,24)17-5-2-14(3-6-17)15-4-7-18-16-8-10-25(9-1-11-26)20(13-16)19(18)12-15/h2-7,12,16,20,26H,1,8-11,13H2
  • Key:DYYGKMZHHOOCGT-UHFFFAOYSA-N

FEM-1689 is a drug which acts as a potent and selective sigma-2 receptor ligand with a binding affinity of 11 nM, and was developed for the treatment of neuropathic pain.

References

  1. Yousuf MS, Sahn JJ, Yang H, David ET, Shiers S, Mancilla Moreno M, et al. (December 2023). "Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response". Proceedings of the National Academy of Sciences of the United States of America. 120 (52): e2306090120. Bibcode:2023PNAS..12006090Y. doi:10.1073/pnas.2306090120. PMC 10756276. PMID 38117854.


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