Frederick or Fred Lewis may refer to:
Sportspeople
- Carl Lewis (Frederick Carlton Lewis, born 1961), American track athlete and Olympic medalist
- Fred Lewis (born 1980), American baseball player
- Fred Lewis (1880s outfielder) (1858–1945), 19th-century American baseball player
- Fred Lewis (basketball, born 1921) (1921–1994), college basketball coach
- Fred Lewis (footballer, born 1886) (1886–1949), English footballer for Stoke
- Fred Lewis (footballer, born 1923) (1923–1975), English footballer for Chelsea and Colchester United
- Fred Lewis (handball) (born 1947), American handball player
- Freddie Lewis (born 1943), American basketball player who played in the National Basketball Association and American Basketball Association
- Frederick Pea (born 1969), American basketball player formerly known as Fred Lewis
- Jack Lewis (footballer, born 1948) (Frederick John Lewis), Wales under-23 international footballer
Others
- Frederick, Prince of Wales (1707–1751), who was sometimes known by his full name Frederick Louis (or Lewis)
- Sir Frederick Orr-Lewis (1860–1921), Canadian businessman
- Fred E. Lewis (1865–1949), American politician
- R. Fred Lewis (born 1947), chief justice of the Florida Supreme Court
- Frederick M. Lewis, known for his contribution to the Mayo–Lewis equation in polymer chemistry
- Frederick Lewis, 1st Baron Essendon (1870–1944), British shipping magnate
- Fred P. Lewis, American meteorologist
- Frederick Christian Lewis (1779–1856), English etcher, engraver and painter
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