Misplaced Pages

Fudosteine

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Chemical compound

Pharmaceutical compound
Fudosteine
Clinical data
Trade namesCleanal
Other namesS-(3-Hydroxypropyl)-L-cysteine
Legal status
Legal status
  • Rx in Japan
Identifiers
IUPAC name
  • (2R)-2-Amino-3-(3-hydroxypropylsulfanyl)propanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC6H13NO3S
Molar mass179.23 g·mol
3D model (JSmol)
SMILES
  • C(CO)CSC(C(=O)O)N
InChI
  • InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
  • Key:KINWYTAUPKOPCQ-YFKPBYRVSA-N

Fudosteine (Cleanal) is a mucolytic agent. In Japan, it is approved for the treatment of bronchial asthma, chronic bronchitis, pulmonary emphysema, bronchiectasis, pulmonary tuberculosis, pneumoconiosis, atypical mycobacterial disease, and diffuse panbronchiolitis.

Fudosteine works by increasing mucin secretion by inhibiting expression of the protein mucin 5AC.

References

  1. Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, et al. (November 2008). "Effect of fudosteine on mucin production". The European Respiratory Journal. 32 (5): 1195–1202. doi:10.1183/09031936.00018508. PMID 18579549.
  2. "Fudosteine". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), U.S. National Institutes of Health.
  3. Antonela Antoniu S (January 2009). "Fudosteine effects on mucin production". Expert Opinion on Investigational Drugs. 18 (1): 105–107. doi:10.1517/13543780802623863. PMID 19053887. S2CID 219294005.
Stub icon

This pharmacology-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: