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GFRAL
Identifiers
Aliases	GFRAL, C6orf144, GRAL, UNQ9356, bA360D14.1, GDNF family receptor alpha like
External IDs	OMIM: 617837; MGI: 3607786; HomoloGene: 45748; GeneCards: GFRAL; OMA:GFRAL - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p12.1 Start 55,327,469 bp End 55,402,493 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 76,071,384 bp End 76,120,939 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle sural nerve right lobe of liver subcutaneous adipose tissue body of pancreas lactiferous gland Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor activity protein binding glial cell-derived neurotrophic factor receptor activity receptor tyrosine kinase binding Cellular component integral component of membrane plasma membrane intracellular anatomical structure membrane external side of plasma membrane receptor complex Biological process negative regulation of neuron apoptotic process stress-activated protein kinase signaling cascade negative regulation of extrinsic apoptotic signaling pathway in absence of ligand reduction of food intake in response to dietary excess glial cell-derived neurotrophic factor receptor signaling pathway positive regulation of MAPK cascade positive regulation of protein kinase B signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389400 404194 Ensembl ENSG00000187871 ENSMUSG00000059383 UniProt Q6UXV0 Q6SJE0 RefSeq (mRNA) NM_207410 NM_205844 RefSeq (protein) NP_997293 NP_995316 Location (UCSC) Chr 6: 55.33 – 55.4 Mb Chr 9: 76.07 – 76.12 Mb PubMed search
Wikidata
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GDNF family receptor alpha like is a protein that in humans is encoded by the GFRAL gene.

See also

• GDNF family of ligands
  • Glial cell line-derived neurotrophic factor (GDNF)
• GDNF family receptor-α (GFRα)

References

1. ^ GRCh38: Ensembl release 89: ENSG00000187871 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000059383 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GDNF family receptor alpha like". Retrieved 2017-09-04.

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: Q6UXV0 (GDNF family receptor alpha-like) at the PDBe-KB.

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