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GNG4

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Protein-coding gene in the species Homo sapiens
GNG4
Identifiers
AliasesGNG4, G protein subunit gamma 4, HG3C
External IDsOMIM: 604388; MGI: 102703; HomoloGene: 3299; GeneCards: GNG4; OMA:GNG4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)
Chromosome 1 (human)Genomic location for GNG4Genomic location for GNG4
Band1q42.3Start235,547,685 bp
End235,650,754 bp
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)
Chromosome 13 (mouse)Genomic location for GNG4Genomic location for GNG4
Band13 A1|13 5.29 cMStart13,958,644 bp
End14,002,481 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • islet of Langerhans

  • ventricular zone

  • Hypothalamus

  • Amygdala

  • left ovary

  • Pituitary Gland

  • caudate nucleus

  • nucleus accumbens

  • prefrontal cortex
Top expressed in
  • facial motor nucleus

  • substantia nigra

  • olfactory bulb

  • lateral septal nucleus

  • islet of Langerhans

  • Rostral migratory stream

  • supraoptic nucleus

  • paraventricular nucleus of hypothalamus

  • molar

  • condyle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2786

14706

Ensembl

ENSG00000168243
ENSG00000282972

ENSMUSG00000021303

UniProt

P50150

P50153

RefSeq (mRNA)

NM_001098721
NM_001098722
NM_004485

NM_010317
NM_001302997

RefSeq (protein)

NP_001092191
NP_001092192
NP_004476

NP_001289926
NP_034447

Location (UCSC)Chr 1: 235.55 – 235.65 MbChr 13: 13.96 – 14 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.

Interactions

GNG4 has been shown to sometimes interact with GNB1.{

References

  1. ^ ENSG00000282972 GRCh38: Ensembl release 89: ENSG00000168243, ENSG00000282972Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021303Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
  6. "Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4".
  7. Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

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Intracellular signaling peptides and proteins
MAP
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Other protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins
Categories:
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