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GNGT1

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Protein-coding gene in the species Homo sapiens

GNGT1
Identifiers
AliasesGNGT1, GNG1, G protein subunit gamma transducin 1, HG3G1
External IDsOMIM: 189970; MGI: 109165; HomoloGene: 7738; GeneCards: GNGT1; OMA:GNGT1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)
Chromosome 7 (human)Genomic location for GNGT1Genomic location for GNGT1
Band7q21.3Start93,591,573 bp
End93,911,265 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for GNGT1Genomic location for GNGT1
Band6|6 A1Start3,993,792 bp
End3,997,436 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • buccal mucosa cell

  • testicle

  • gonad

  • placenta

  • paraflocculus of cerebellum

  • amniotic fluid

  • Epithelium of choroid plexus

  • monocyte

  • thymus
Top expressed in
  • neural layer of retina

  • retinal pigment epithelium

  • epithelium of lens

  • pineal gland

  • lumbar subsegment of spinal cord

  • lumbar spinal ganglion

  • ciliary body

  • iris

  • internal carotid artery

  • external carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2792

14699

Ensembl

ENSG00000127928

ENSMUSG00000029663

UniProt

P63211

Q61012

RefSeq (mRNA)

NM_021955
NM_001329426

NM_010314

RefSeq (protein)

NP_001316355
NP_068774

NP_034444

Location (UCSC)Chr 7: 93.59 – 93.91 MbChr 6: 3.99 – 4 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene. Either GNGT1 or GNGT2 is the gamma subunit (Gγ) of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (Gα) subunit.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000127928Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029663Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (Sep 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)". Genomics. 35 (1): 241–3. doi:10.1006/geno.1996.0346. PMID 8661128.
  6. "Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".
  7. Lagman D, Sundström G, Ocampo Daza D, Abalo XM, Larhammar D (2012). "Expansion of transducin subunit gene families in early vertebrate tetraploidizations". Genomics. 100 (4): 203–211. doi:10.1016/j.ygeno.2012.07.005. PMID 22814267.
  8. Lerea CL, Somers DE, Hurley JB, Klock IB, Bunt-Milam AH (October 1986). "Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors". Science. 234 (4772): 77–80. Bibcode:1986Sci...234...77L. doi:10.1126/science.3529395. PMID 3529395.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: P02698 (Bovine Guanine nucleotide-binding protein G(T) subunit gamma-T1) at the PDBe-KB.
PDB gallery
  • 1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA 1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
  • 1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN 1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
  • 1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA 1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
  • 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
  • 1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN 1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
  • 2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX 2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
Intracellular signaling peptides and proteins
MAP
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Other protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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