| GRAM domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Myotubularin-related protein 2 | |||||||||
| Identifiers | |||||||||
| Symbol | GRAM | ||||||||
| Pfam | PF02893 | ||||||||
| Pfam clan | CL0266 | ||||||||
| InterPro | IPR004182 | ||||||||
| SMART | GRAM | ||||||||
| SCOP2 | 1lw3 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 130 | ||||||||
| OPM protein | 1zvr | ||||||||
| CDD | cd10570 | ||||||||
| Membranome | 349 | ||||||||
| |||||||||
The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins. The structure of the GRAM domain is similar to that found in PH domains.
Proteins containing GRAM domains are found in all eukaryotes and bacteria, but not archaea. Various GRAM domains can bind proteins or lipids.
Human proteins containing this domain
GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2A; GRAMD2B; GRAMD4; MTM1; MTMR1; MTMR2; NCOA7; NSMAF; OXR1; SBF1; SBF2; TBC1D8; TBC1D8B; TBC1D9; TBC1D9B; WBP2; WBP2NL; dJ439F8.1;
References
- Doerks T, Strauss M, Brendel M, Bork P (October 2000). "GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins". Trends Biochem. Sci. 25 (10): 483–5. doi:10.1016/S0968-0004(00)01664-9. PMID 11050430.
- Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (December 2003). "Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome". Mol. Cell. 12 (6): 1391–402. doi:10.1016/S1097-2765(03)00486-6. PMID 14690594.
- ^ Jiang SY, Ramamoorthy R, Ramachandran S (February 2008). "Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes". Dev. Biol. 314 (2): 418–32. doi:10.1016/j.ydbio.2007.11.031. PMID 18201690.
 | This membrane protein–related article is a stub. You can help Misplaced Pages by expanding it. |