George Pyke may refer to:
- George Pyke (politician) (1775–1851), lawyer, judge and political figure in Lower Canada
- George Pyke (footballer) (1887–1960), Australian rules footballer for Fitzroy
- George Woolston Pyke (1893–1977), English footballer
- George Alexander Pyke, Lord Tilbury, a fictional character in the stories of British author P. G. Wodehouse
See also
- George Pike (1923–2007), Australian rules footballer for Geelong
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