George Spence may refer to:
- George Spence (Canadian politician) (1880–1975), Canadian provincial and federal politician
- George Spence (MP) (1787–1850), Member of Parliament for Ripon, 1829–1832
- George Spence (footballer, born 1877) (1877–?), Scottish football player for Preston, Southampton and Hull
- George Spence (footballer, born 1904) (1904–?), English football player for Nelson
Topics referred to by the same termThis disambiguation page lists articles about people with the same name. If an internal link led you here, you may wish to change the link to point directly to the intended article. Category: