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In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (EC 1.2.1.59) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ ${\displaystyle \rightleftharpoons }$ 3-phospho-D-glyceroyl phosphate + NAD(P)H + H

The 4 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, NAD, and NADP, whereas its 4 products are 3-phospho-D-glyceroyl phosphate, NADH, NADPH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating). Other names in common use include (phosphorylating), triosephosphate dehydrogenase (NAD(P)), and glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2CZC.

References

• P. Mathis (Ed.), Photosynthesis: From Light to Biosphere, vol. 1, Kluwer Academic Publishers, 1995, p. 959-962.
• Valverde F, Losada M, Serrano A (1997). "Functional complementation of an Escherichia coli gap mutant supports an amphibolic role for NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase of Synechocystis sp. strain PCC 6803". J. Bacteriol. 179 (14): 4513–22. doi:10.1128/jb.179.14.4513-4522.1997. PMC 179286. PMID 9226260.

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