"Great Scott!" is an exclamation of surprise, amazement, or dismay.
Great Scott may also refer to:
- Great Scott (lunar sample), a 21-pound rock picked up on the moon by Commander David Scott of Apollo 15
- Great Scott! (TV series), an American sitcom that aired in 1992
- Great Scott Township, St. Louis County, Minnesota
- The Great Scott, ring name for Canadian professional wrestler, booker and promoter George Scott
- Great Scott Films Inc, co-founded by Christopher J. Scott
- Great Scott! The Best of Jay Scott's Movie Reviews, a collection of reviews by Canadian film critic Jay Scott
- Nickname of A Greek–English Lexicon, specifically the longest editions of the work (Robert Scott is one of the co-authors)
- Great Scott was a famous miniseries on BNN featuring Scott Harris
Music
- "Great Scott Rag", a 1909 composition by James Scott
- Great Scott! (1958 Shirley Scott album)
- Great Scott!!, an album by Shirley Scott released in 1964
- Great Scott! (1991 Shirley Scott album)
- Great Scott!, compilation album by Little Jimmy Scott
- Great Scott (opera), a 2015 opera by composer Jake Heggie and librettist Terrence McNally
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