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Great Siege may refer to:

• Great Siege of Gibraltar, 1779–1783, an unsuccessful attempt by Spain and France to capture Gibraltar from Britain
• Great Siege of Malta, 1565, an unsuccessful attempt by the Ottoman Empire to capture Malta from the Order of Saint John
• Great Siege of Montevideo, 1843–1851, during the Uruguayan Civil War
• Great Siege of Scarborough Castle, 1645, during the English Civil War

• Disambiguation pages