Guillemette may refer to:
People
- Alphonse-Edgar Guillemette (1877–1950), Canadian politician
- Éloi Guillemette (1911–1984), Canadian politician
- Hélène Guillemette, Canadian politician
- Joanne Guillemette, U.S. politician
- Nancy Guillemette, Canadian politician
- Guillemette Andreu (born 1948), French Egyptologist and archaeologist
- Guillemette du Luys (fl. 1479), French surgeon
- Guillemette Laurens (born 1957), French opera singer
- Guillemette of Neufchâtel (1260–1317), French noblewoman
- Guillemette de Sarrebruck (1490–1571), French court official
See also
- Guillemet, a punctuation mark
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