Gwilliam or Gwilym or Gwilliams may refer to:
- Gwilliam (surname)
- Brad Gwilliam (born 1966), Australian rules footballer
- Dianna Gwilliams (born 1957), educator
- Edward Gwilliam, English footballer
- George Gwilliam, English Aramaicist
- John Gwilliam (1923–2016), Welsh rugby union player and schoolteacher
- Gwilliam (given name)
- Gwilym Iwan Jones (1904–1995), Welsh photographer and anthropologist
- Gwilliam v West Hertfordshire Hospital NHS, English tort law case concerning occupiers' liability
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