H1299, also known as NCI-H1299 or CRL-5803, is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.
As with other immortalized cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which in part accounts for their proliferative propensity. These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP).
References
- "NCI-Navy Medical Oncology Branch cell line supplement". J. Cell. Biochem. Suppl. 24: 1–291. 1996. PMID 8965489.
- "ATCC Advanced Catalog Search". Retrieved 2009-01-07.
- "CRL-5803/NCI-H1299 cell line". LGC Promochem: Cell Biology Collection. American Type Culture Collection. Retrieved 2008-06-22.
- ^ Giaccone G, Battey J, Gazdar AF, Oie H, Draoui M, Moody TW (May 1992). "Neuromedin B is present in lung cancer cell lines". Cancer Res. 52 (9 Suppl): 2732s – 2736s. PMID 1563005.
- Lin DL, Chang C (June 1996). "p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily". J. Biol. Chem. 271 (25): 14649–52. doi:10.1074/jbc.271.25.14649. PMID 8663350.
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