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HEBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R85, 3R8J, 3R8K, 4AYZ, 4B0Y
Identifiers
Aliases	HEBP2, C6ORF34B, C6orf34, PP23, SOUL, heme binding protein 2
External IDs	OMIM: 605825; MGI: 1860084; HomoloGene: 8634; GeneCards: HEBP2; OMA:HEBP2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q24.1 Start 138,403,531 bp End 138,422,197 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A3 Start 18,415,246 bp End 18,421,824 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland amniotic fluid gums gingival epithelium vulva Skeletal muscle tissue of biceps brachii skin of thigh right ventricle adipose tissue oral cavity Top expressed in facial motor nucleus esophagus transitional epithelium of urinary bladder skin of external ear skin of abdomen lip epithelium of lens motor neuron conjunctival fornix cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding heme binding Cellular component cytoplasm extracellular exosome mitochondrion extracellular region azurophil granule lumen Biological process negative regulation of mitochondrial membrane potential positive regulation of necrotic cell death regulation of response to reactive oxygen species positive regulation of mitochondrial membrane permeability neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23593 56016 Ensembl ENSG00000051620 ENSMUSG00000019853 UniProt Q9Y5Z4 Q9WU63 RefSeq (mRNA) NM_014320 NM_001326380 NM_001326381 NM_019487 RefSeq (protein) NP_001313309 NP_001313310 NP_055135 NP_062360 Location (UCSC) Chr 6: 138.4 – 138.42 Mb Chr 10: 18.42 – 18.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Heme-binding protein 2 is a protein that in humans is encoded by the HEBP2 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000051620 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000019853 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zylka MJ, Reppert SM (Feb 2000). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Res Mol Brain Res. 74 (1–2): 175–81. doi:10.1016/S0169-328X(99)00277-6. PMID 10640688.
6. Szigeti A, Bellyei S, Gasz B, Boronkai A, Hocsak E, Minik O, Bognar Z, Varbiro G, Sumegi B, Gallyas F Jr (Nov 2006). "Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL". FEBS Lett. 580 (27): 6447–54. doi:10.1016/j.febslet.2006.10.067. PMID 17098234. S2CID 19675303.
7. "Entrez Gene: HEBP2 heme binding protein 2".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
• Bohn H, Winckler W (1991). "Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26)". Arch. Gynecol. Obstet. 248 (3): 111–5. doi:10.1007/BF02390087. PMID 2018407. S2CID 23535410.

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