Misplaced Pages

Homocysteine desulfhydrase

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Enzyme
homocysteine desulfhydrase
Identifiers
EC no.4.4.1.2
CAS no.9024-41-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme homocysteine desulfhydrase (EC 4.4.1.2) catalyzes the chemical reaction

L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate (overall reaction)
(1a) L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous)
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming). Other names in common use include homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase (deaminating). This enzyme participates in nitrogen and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.

References

Carbon–sulfur lyases (EC 4.4)
4.4.1
Enzymes
Activity
Regulation
Classification
Kinetics
Types
Portal:


Stub icon

This enzyme-related article is a stub. You can help Misplaced Pages by expanding it.

Categories: