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This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming). Other names in common use include homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase (deaminating). This enzyme participates in nitrogen and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.